Large scale PTM - PPI relation extraction

Overview

Build Status

Large-scale protein-protein post-translational modification extraction with distant supervision and confidence calibrated BioBERT

docs/images/Overview.png

The silver standard data is available https://github.com/elangovana/large-scale-ptm-ppi/releases/download/v1.0.0/distant_silver_data.zip

PTM-PPI Dataset relation extraction

AIMed PPI relation extraction

Download AIMed dataset

  1. Download from ftp://ftp.cs.utexas.edu/pub/mooney/bio-data/interactions.tar.gz

  2. Convert the raw dataset into XML for using instructions in http://mars.cs.utu.fi/PPICorpora/

    convert_aimed.py -i  aimed_interactions_input_dir -o aimed.xml
    

Run

Step 1: Convert xml AIMed to flattened json

python src/preprocessors/aimed_json_converter.py --inputfile tests/sample_data/aimed.xml --outputfile aimed.json

Step 2: 10 fold split

You can either choose random split, or split by unique documents

[Option R - Random ] This randomly splits into n folds

python src/preprocessors/kfold_aimed_json_splitter.py --inputfile aimed.json --outputdir temp_data/kfolds_random  --kfoldLabelColumn interacts --k 10

[Option U - Unique Document] This splits into n folds, taking into account document id uniqueness

python src/preprocessors/kfold_aimed_json_splitter.py --inputfile aimed.json --outputdir temp_data/kfolds_unique  --kfoldLabelColumn interacts --k 10  --kfoldDocId documentId

Step 3: Run training

python src/main_train.py --datasetfactory datasets.aimed_dataset_factory.AimedDatasetFactory --traindir temp_data/kfold_unique --modeldir temp_data --outdir temp_data --kfoldtrainprefix train  --model_config '{"vocab_size": 20000, "hidden_size": 10, "num_hidden_layers": 1, "num_attention_heads": 1, "num_labels": 2}' --tokenisor_data_dir tests/sample_data/tokensior_data --epochs 1 --numworkers 1

Utils

  1. To create the preprocessed file with protein names replaced with markers
python utils/static_markers_ppi_multiclass.py --inputfile /Users/aeg/PycharmProjects/ppi-aimed/temp_data/data/laregscale_hq_above_threshold.json  --outputfile markers_largescale_multiclass.json  --additionalcols "class,confidence"
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Comments
  • CVE-2007-4559 Patch

    CVE-2007-4559 Patch

    Patching CVE-2007-4559

    Hi, we are security researchers from the Advanced Research Center at Trellix. We have began a campaign to patch a widespread bug named CVE-2007-4559. CVE-2007-4559 is a 15 year old bug in the Python tarfile package. By using extract() or extractall() on a tarfile object without sanitizing input, a maliciously crafted .tar file could perform a directory path traversal attack. We found at least one unsantized extractall() in your codebase and are providing a patch for you via pull request. The patch essentially checks to see if all tarfile members will be extracted safely and throws an exception otherwise. We encourage you to use this patch or your own solution to secure against CVE-2007-4559. Further technical information about the vulnerability can be found in this blog.

    If you have further questions you may contact us through this projects lead researcher Kasimir Schulz.

    opened by TrellixVulnTeam 0
Releases(v1.0.0)
  • v1.0.0(Dec 13, 2021)

    This is release is the code used for published paper. The silver standard dataset using distant supervision is attached.

    1. The raw files contain the data that require to be processed with markers. Read the json file using python
    import pandas as pd
    pd.read_json("./raw/train_multiclass.json")
    
    
    1. The processed files contain the data that are processed with markers. Read the json file using python
    import pandas as pd
    pd.read_json("./processed/train_multiclass.json", orient="records")
    
    
    Source code(tar.gz)
    Source code(zip)
    distant_silver_data.zip(932.68 KB)
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